Detalhe da pesquisa
1.
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.
J Biol Chem
; 290(25): 15730-15745, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25931126
2.
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).
BMC Biotechnol
; 16: 23, 2016 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26911368
3.
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Bioconjug Chem
; 25(7): 1331-41, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24924618
4.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
5.
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
J Immunother Cancer
; 10(9)2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36100308
6.
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J Biol Chem
; 285(5): 3417-27, 2010 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19923222
7.
Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction.
Antibodies (Basel)
; 10(1)2021 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33671864
8.
Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies.
Antibodies (Basel)
; 9(4)2020 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33266498
9.
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening.
MAbs
; 12(1): 1743053, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32249670
10.
Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.
Eur J Med Chem
; 88: 3-9, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25176286
11.
Development of an enzyme-linked immunosorbent assay (ELISA) to measure the level of tyrosine hydroxylase protein in brain tissue from Parkinson's disease models.
J Neurosci Methods
; 215(2): 245-57, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23537934
12.
Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target.
PLoS One
; 8(7): e66879, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23861750
13.
Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
ChemMedChem
; 8(8): 1295-313, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23794260
14.
Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
PLoS One
; 7(7): e40443, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22792325
15.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552
16.
Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells.
J Immunol
; 173(4): 2324-30, 2004 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294945
17.
The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern.
Proc Natl Acad Sci U S A
; 101(1): 260-5, 2004 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14691262